Drug - Sprix (ketorolac) nasal spray [Roxro Pharma]
July 2011
Therapeutic Area - Pain
Indicated for short-term (up to five days) management of moderate to moderately severe pain that requires analgesia at the opioid level.
The usual dosage is 31.5 mg (one 15.75 mg spray in each nostril) every six to eight hours. The maximum daily dose is 136 mg. Sprix nasal spray should not be used for longer than five days. Longer use increases the risk of serious complications including gastrointestinal bleeding and renal injury.
A quantity limit of 5 bottles (one per day) applies. This is a safety consideration, and more than five bottles will not be approved.
Efficacy data shows that Sprix, used for 2 days, added to morphine after elective surgery, worked better than morphine alone to improve pain scores. Yet, Sprix represents a costly dose formulation of ketorolac.
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