Drug - Lyrica (Pregabalin)
June 2012
Therapeutic area - Neuropathic Pain, Partial Onset Seizures
PA criteria are limited to FDA approved indications.
Prescriptions should be managed within the quantity limits.
Lyrica Strength | Quantity limit/Month |
25 mg, 50 mg, 75 mg, 100 mg, 150 mg, 200 mg, 225 mg | 90 |
300 mg | 60 |
Adjunctive therapy for adult patients with partial onset seizures
Management of neuropathic pain after spinal cord injury
Management of neuropathic pain associated with diabetic peripheral neuropathy*
Management of postherpetic neuralgia*
Fibromyalgia*
*Multiple PA’s for one individual are not allowed, except for patients with a diagnosis of partial onset seizures.
Lyrica was shown to benefit some patients who had a fibromyalgia pain score ≥ 4 on a scale of 0 to 10. Whereas about 28% of placebo-treated patients had an improvement of ≥30% in pain from baseline, about 35-40% of Lyrica-treated patients had this same degree of improvement.4 Whereas about 17% of placebo-treated patients reported a 50% improvement in pain scores, about 23% of Lyrica-treated patients showed a 50% improvement in pain scores.4 There is a dose-dependent benefit to Lyrica to a maximum of 450 mg. 600 mg did not improve pain scores but increased the incidence of side effects.4
1 Lawson K. Tricyclic antidepressants and fibromyalgia: what is the mechanism of action? Expert Opin Investig Drugs. 2002;11:1437-45.
2 Arnold LM. Biology and therapy of fibromyalgia. New Therapies for fibromyalgia. Arthritis Research and Therapy. 2006;8:212. can be found at http://arthritis–research.com/content/8/4/212.
3 Arnold, LM et al. Gabapentin in the treatment of fibromyalgia; a randomized, double-blind, placebo-controlled multicenter trial. Arthritis Rheum. 2007; 56: 1336-1344.
4 Lyrica prescribing information. Pfizer Pharmaceuticals. June 2007
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