Opana and Opana ER
Drug - Opana and Opana ER (oxymorphone) tablets
March 2008
Description
Oxymorphone is a potent semi-synthetic narcotic analgesic that is a narcotic substitute for morphine. Oral oxymorphone is more potent than oral morphine (3x), hydrocodone (2x), and oxycodone (2x). Elderly patients and renally impaired patients may have a 40-65% increase in bioavailability.
Strengths available
Opana
Opana ER
- 5 mg
- 7.5 mg
- 10 mg
- 10 mg
- 15 mg
- 20 mg
- 30 mg
- 40 mg
Criteria
- Opana is being used for the relief of moderate to severe pain where the use of an opioid is appropriate AND
- Patient is under the care of a pain management specialist AND
- Patient has intolerable side effects to ALL of the opioids listed below, and the adverse effects prevented upward titration of dosage to achieve a satisfactory level of analgesia AND
- Patient has been warned that:
- Co-administration with alcohol may increase oxymorphone plasma levels and the risk of potentially fatal toxicity
- Opana should be taken on an empty stomach since food can increase the rate of absorption by 50% AND
- Patient does not have moderate and severe hepatic impairment (contraindicated) or a paralytic ileus
Oxymorphone formulation and prior opioid trials required
Immediate-release |
Hydrocodone with or without acetaminophen (Lorcet, Lortab, Vicoden)
Morphine
Oxycodone (Percocet, Percodan)
Hydrodmorphone (Dilaudid) |
Extended-release |
Morphine
Oxycodone
Fentanyl transdermal |
Questions?
MHCP Provider Call Center 651-431-2700 or 800-366-5411